Honey and Infant Botulism

Not giving your infant honey is an important preventive health measure. It may save her life. The concern is honey and infant botulism.

Question

My daughter is now 7 months old. I have been adding locally produced honey to my daughter's food to help with her allergies. In my opinion, this has decreased her allergy like symptoms. My wife and I have had great success decreasing our allergies with this practice. I was told that honey can hurt an infant. Is this true?
Mark Torrans - Pineville, Louisiana

Dr. Greene's Answer

Mark, your care for your daughter comes through clearly in your question. Taking the initiative with preventive measures to insure her health and comfort is a very loving act. Getting information regarding the safety and efficacy of these preventive measures is very wise indeed and may save your daughter’s life.

First, the good news about honey

Like you, I have heard claims that wild honey might reduce allergy symptoms. In fact, today in a local supermarket, I saw a jar labeled “100% Natural Raw Honey, Unfiltered Unblended.” This product went on to promise great health benefits.

And indeed, scientific study has recognized great medicinal value in honey. Honey has been used for over 8000 years in traditional medicine, as depicted by Stone Age drawings. It currently plays an important role in modern medicine as well. Honey has been found to have antibacterial, anti-inflammatory, and even important antioxidant properties. Its use in wound and burn care is well established. It may help in improving digestive health and gastrointestinal disorders, and can even help with sleep and suppression of irritating coughs. The benefits of honey are impressive and far-reaching.. 

Now, the important bad news about honey for infants

As it turns out, NOT giving your daughter honey while she is an infant is an important preventive health measure. It may save her life.

The concern is with infant botulism.

Botulinum spores are found widely in soil, dust, and honey. Adults who swallow botulinum spores are almost never affected. When infants swallow the spores, however, the spores can germinate in their immature gastrointestinal tracts and begin producing botulinum toxin. This has occurred even when the honey was only used to sweeten a pacifier. In 2018, four infants in Texas were diagnosed with infant botulism thought to be caused by honey-sweetened pacifiers.  This led to a resurgence of public health advisories and educational messages about the potential dangers of honey given to infants under 12 months of age. 

Botulinum toxin is the most poisonous natural substance known to man. The lethal dose is only 0.0000001 mg per kg of bodyweight — an amount that would be invisible to the naked eye. This tiny amount in the bloodstream can cause death within minutes through paralysis of the muscles used in breathing.

Infant botulism has been found on every continent except Africa. In the United States, it is most common in the states of California, Utah, and Pennsylvania. While infant botulism can occur from taking in soil or dust (especially vacuum cleaner-bag dust), eating honey is a more easily preventable cause.

Infant botulism can occur any time in the first year of life; but like SIDS, it is most common in the first six months. In fact, two studies state that botulinum toxin has been found in 4-15% of postmortem SIDS cases. However, another 10-year prospective study did not find a connection.  A history of honey intake is seen in at least 15% of cases of infant botulism. 

Thankfully, in most instances of infant botulism, the amount of toxin is so incredibly minuscule that the case remains mild. For this reason, it is often misdiagnosed.

The first symptom of infant botulism is constipation (which is also a common benign finding in many infants). This can appear 3 to 30 days following ingesting spore-containing honey. Typically, the parents then observe increasing listlessness, decreased appetite, and weakened cry over the next several days. Nursing mothers often report new engorgement. Sometimes this is the full extent of the disease. If the disease progresses, however, the child moves less and less and might begin to drool from the mouth. Gagging and sucking reflexes diminish. Loss of previous head control is also an important sign. Parents will often describe lethargy and abnormal irritability in their infants. Complete respiratory arrest can occur either suddenly or gradually.

If an otherwise healthy baby develops constipation, followed by weakness and difficulty in sucking, crying, or breathing, then infant botulism should be considered the most likely diagnosis until proven otherwise. If you notice these signs, you should seek immediate medical care. 

When infant botulism is diagnosed, the average Intensive Care Unit stay for the baby is about one month, typically including mechanical ventilation and continuous tube feedings.  Thankfully, if the botulism is correctly diagnosed and the baby receives appropriate supportive care, almost all will recover fully and completely. The fatality rate for babies who have been hospitalized with botulism is less than 1%. An antitoxin for infant botulism, trade name “BabyBIG,” is a human-derived botulism immune globulin that has been shown to reduce hospital days, mechanical ventilation, and tube feedings.

The single most effective way to prevent infant botulism is for infants to avoid honey. Breastfeeding also appears to lessen the severity of botulism cases, although is not protective against contracting the disease.

Therefore, despite other health benefits, honey is an unsafe food for any infant. Accordingly, the American Academy of Pediatrics (AAP), Food and Drug Administration (FDA), and the Centers for Disease Control and Prevention (CDC) state that HONEY SHOULD NOT BE GIVEN TO CHILDREN YOUNGER THAN 12 MONTHS.

Breastfeeding, though, is a great way to prevent or decrease allergy symptoms. Breastfeeding and minimizing your daughter’s being exposed to potential allergens (such as cigarette smoke, cat hair, house dust, etc.) are the best ways to serve your goals of reducing her allergies and her allergy symptoms. These measures will benefit your daughter now, and the benefit will last for years to come.

References and Resources

Ashkin E, Mounsey A. PURLs: a spoonful of honey helps a coughing child sleep. J Fam Pract. 2013; 62(3):145-147.

Brook, I.  Infant Botulism. Journal of Perinatology 2007; 27:175–180.

Byard RW, Moore L, Bourne AJ, Lawrence AJ, Goldwater PN. Clostridium botulinum and sudden infant death syndrome: a 10-year prospective study. J Paediatr Child Health 1992; 28:156–7.

Cox N, Hinkle R. Infant botulism. Am Fam Physician 2002; 65(7):1388-1392.

Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci. 2013; 16(6):731-742.

FDA, Honey Pacifiers suspected in Infant Botulism cases

The Red Book. Committee on Infectious Diseases; American Academy of Pediatrics; 2018.

Wigginton JM, Thill P. Infant botulism: a review of the literature. Clin Pediatr 1993; 32:669–74.

Last medical review on: January 05, 2021
About the Author
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Dr. Greene is a practicing physician, author, national and international TEDx speaker, and global health advocate. He is a graduate of Princeton University and University of California San Francisco.
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Pls I have given raw honey to my four month baby, what medicine can I give to him

Dear Rhianatu,

I can hear the fear in your question. I’m so sorry.

Per Dr. Greene, “The problem with infant botulism comes when a child has it and no one suspects it. It’s wise to be on the lookout for symptoms and report them to your baby’s pediatrician. The odds of having a problem are still quite small and even it if happens, your being alert is the best gift you can give.”

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

Dear Rhianatu,

I can hear the fear in your question. I’m so sorry.

Per Dr. Greene, “The problem with infant botulism comes when a child has it and no one suspects it. It’s wise to be on the lookout for symptoms and report them to your baby’s pediatrician. The odds of having a problem are still quite small and even it if happens, your being alert is the best gift you can give.”

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

I think after 12 months old there’s not much risk. There may not be much risk even younger. I wouldn’t have her checked, but if she’s constipated and has other symptoms, then I would.

I gave my 21 month old some raw manuka honey (1/4 teaspoon) for her cough. 2-3 hours later she had a vomiting fit. But the next day she was all fine. It’s been 3 days now and she seems fine. Her appetite is normal and no constipation. She’s active as usual. Just wondering should I be worried about botulism? Should I have her checked immediately or just wait and see?

I think after 12 months old there’s not much risk. There may not be much risk even younger. I wouldn’t have her checked, but if she’s constipated and has other symptoms, then I would.

How long ago did your baby eat honey?
Best,
@MsGreene

How many percentage that my baby will have infant botulism after intake of honey ?? My baby have constipation but other than that no have any symptoms occur .. We already bring him to doctor and ask that he intake honey , just the doctor check his bowel and asking no have problem. But as I read here I’m still worried even doctor ask me that no have problem ..

How long ago did your baby eat honey?
Best,
@MsGreene

Hi April,

You can relax.

The impact of botulism is usually seen within hours. It can take up to 10 days to appear, but not months.

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

15 month old

Hi April,

You can relax.

The impact of botulism is usually seen within hours. It can take up to 10 days to appear, but not months.

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

I was a young married mother. I gave birth to a healthy baby girl in November 1979. She passed away from SIDS April 1979. Step grama did not like the baby, but my husband and I visited daily cause Grampa loved the baby. She Grama was a RN. She had a daily routine of giving baby honey. All these years later and what I’ve learned about honey, I think she purposely killed my baby. Is it too late to have authorities investigate this?

Yes, he was constipated. Other than that, there wasn’t any other signs I remember. But constipation was one because the doctors kept telling me since he was breast fed it’s okay for them to not pass a bowel movement for sometime. Not sure if t was just coincidence or if the constipation was actually related to the botulsm.