High-dose Amoxicillin

Question

My 26-month-old, 26-pound daughter was diagnosed as having an ear infection. Her doctor put her on amoxicillin--500 mg, twice a day. Everyone is telling me that 1000 mg per day is an awful lot. What do you think?

Dr. Greene's Answer

The best dose of amoxicillin has changed in recent years. The change to high-dose amoxicillin came because many bacteria were getting partially resistant to it. Rather than switching to antibiotics that are broader spectrum or with more side effects, high-dose amoxicillin is considered the most effective and safest of the first line treatments.

The recommended dosage used to be 10 to 30 mg per kg of body weight per day. But for ear infections, it is now better to give 60 to 80 mg per kg per day. For her, that would be somewhere between 750 and 1000 mg daily. The timing between doses does not need to be precise, but the farther apart the doses are, the lower the chances of diarrhea as a side effect.

Generally speaking, amoxicillin is a very safe and well tolerated medication, even at the higher doses. However, antibiotics do kill beneficial bacteria as well, and the more effective the antibiotic, the more likely this will happen. Eating yogurt with active cultures is a great way to replenish them. Some of the frozen varieties are the most effective.

Last medical review on: February 12, 2009
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Dr. Greene is a practicing physician, author, national and international TEDx speaker, and global health advocate. He is a graduate of Princeton University and University of California San Francisco.
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Dear Lucinda,

Dr. Greene discusses antibiotic use and overuse in this article. He suggestes you read it, print it, take it to your doctor.

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

My husband is on a high dosage of Amoxicillin 500 mg. Two in the morning, two at lunch and two at dinner. Now the doctor said that he doesn’t have a bacterial infection because my husband is still coughing, no fever or sinus trouble. The doctor said to complete the medication. That means another week of this. He’s been sick for 7 weeks now and his doctor said that he has a bad cold.

Dear Lucinda,

Dr. Greene discusses antibiotic use and overuse in this article. He suggestes you read it, print it, take it to your doctor.

I hope that helps.
Best, @MsGreene
Note: I am the co-founder of DrGreene.com, but I am not Dr. Greene and I am not a doctor. Please keep that in mind when reading my comments and replies.

My 4 year old, weighing 35 pounds was suggested 657 mg of Amoxicillin 2 times a day i.e. total 1350 mg per day. He developed rashes all over the body in a week. Was he given overdose of Amoxicillin?

I’ve H. pylori, My Dr. prescribed 2000 mg of Amoxicilin daily plus 1000
of Clarithromycin to much? I’m 75 years old.
Thank you

I have been prescribed 1625 for strep throat; so far it has done nothing. Was going to increase it to 2625 a day. Is that dangerous or just see how you react.

My baby was 5 months old 16lbs prescribed 400mg twice a day on Friday by Monday she was hospitalized for uncontrollable seizures and has been seizing since and she is now 3 yrs old. I was told 800mg a day was to much for a baby who had a bad cold or “touch of pneumonia” she was born perfectly healthy with no health problems until I gave her amoxicillin. Was that too much for her?

My grand child who is 25 pounds and 18 months old was prescribed 7ml 400 mg amoxicillin two times a day. Was wondering isn’t this too much for the little one? She was a resident doctor and told he has a slight ear infection.
Thanks

My mom is 98 years old, just left hospital had pneumonia and a UTI. I’m concerned over the antibiotic amox-clav250-62mg/5. 10-ML oral every 12 hrs. Mom is very susceptible to C-Diff. She has had 2 doses and already had diarrhea, should I lower dosage? Help?

Yep it’s a lot. I have same dose. I felt like I was gonna die the first few days. Here the key… EAT A HEAVY MEAL morning n evening when u take this crazy pill-combo (skip lunch if u want). Trust me, u don’t want h-p lingering in your system. So yeah it’s a lot but HIT IT HARD. Then take the “natural remedies/supplements for h-p” when your done with the antibiotic.

Take the triple-combo of antibiotics for h-p!
Don’t let it linger.