Cefdinir is an antibiotic used to treat many different types of bacterial infections in children. You might see a brand name such as Omnicef on the label. It belongs to the cephalosporin family of antibiotics (“cousins” to the penicillins). This antibiotic comes as strawberry and cream flavored liquid or as capsules.

Either form can be given with or without food. However, cefdinir should be taken at least two hours before any multivitamins with iron, iron supplements, or antacids that contain magnesium or aluminum, because these can interfere with the absorption of the antibiotic. Infant formula with iron does not pose a problem.

Liquid cefdinir should be shaken before giving each dose. To get the correct dose, skip the silverware spoon and use a measuring spoon or dose-measuring device (ask your pharmacist for one if you don’t have one). It may be stored at room temperature. Discard any unused cefdinir 10 days after it was first prepared by the pharmacist.

Cefdinir is a recommended first antibiotic for some children with ear infections who are allergic to amoxicillin. It can be taken once or twice a day. Taking the dose once a day is usually as effective as dividing the dose in two, but the smaller doses may be gentler on the stomach. If you happen to miss a twice-a-day dose, you can go ahead and give it late, but try not to give once-a-day doses within about 12 hours of each other. If you happen to give too much at once (more than two doses), seek medical advice.

If your child is taking cefdinir for an ear infection, you should expect improvement within 48 to 72 hours. If not, contact your doctor to discuss switching to another antibiotic, such ceftriaxone or clindamycin.

Do Not use cefdinir if your child is known to be allergic to this or to any of the cephalosporin antibiotics, such as cephalexin, cefuroxime, or ceftriaxone. Other antibiotic options might include azithromycin, clarithromycin, or clindamycin. Be sure the prescribing doctor knows if your child has any other medication allergies (especially to penicillins), or has kidney disease, intestinal problems. Be sure to report any other medicines your child might be taking.

Diarrhea is a common side effect of antibiotics. Whenever antibiotics are given, consider also giving your child probiotics (beneficial bacteria). Out of ten well-designed studies, nine showed significantly less diarrhea in the children receiving probiotics (the studies used between 5 and 40 billion cfu per day). Probiotics are available as supplements or in some foods and beverages (yogurt, kefir, juice). Whatever you choose, look for at least 5 billion colonies.

Get emergency care if your child is showing signs of a serious allergic reaction, such as difficulty breathing, spreading hives, or swelling of the lips, tongue, or throat.

Other side effects are possible with this or any medication. Be sure to report unexpected new symptoms to your healthcare provider. Whether they are caused by the antibiotic or by the illness getting worse, unexpected symptoms are important to report.

AAP Clinical Practice Guideline. Diagnosis and management of acute otitis media. Pediatrics, May 2004, 113(5):1451-1465.

Johnston BC, Supina AL, Ospina M, Vohra S. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD004827. DOI: 10.1002/14651858.CD004827.pub2.

Published on: June 18, 2009
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Recent Comments

My daughter was prescribed this today for her ear and severe sinuses …I know about the diarrhea but is this a good medicine…do I need to worry ??

My son has been on amoxicillin for 6 days now for an ear infection and also has a bad respiratory virus. Yesterday, he started to develop a rash on his torso. Today it is much worse and has spread all over the face, neck and body and is extremely itchy. Benedryl does not seem to be working to control the rash or itching and he is miserable.
We have seen the dr and have been instructed to stop the amoxicillin and now wants him to finish his antibiotics course with CEFDINIR. Would that be ok seeing that it also causes similar allergic rashes? Considering the rash is widespread all over the body, how will I even know if he is allergic to the new medication and it would be making it worse?
When can I expect the rash to go away and what can I do to alleviate the itch? He is being tortured by the discomfort and I feel helpless.

I have been giving my 8 month old son Cefdinir for 4 days already. The pharmacist told me to give it to him two times daily. I didn’t know about not giving them the once-a-day dosage within 12 hours. I have been giving it to him 10 hours apart. I give him 2.4 ml at 10:30AM and again at 8:30PM. Is this dangerous for him?

I gave my 4 year old child a 6 ml dose of Cefdinir at 6pm last night and again this morning at 8am . I didn’t realize this was a once a day dosage and I’m afraid I gave the doses too close together (I realize I should have waited 24 hours, after the fact).

Is this dangerous? Will she be OK?