Could a rise in cases of Pyloric stenosis be linked to erythromycin?

Could a rise in cases of Pyloric stenosis be linked to erythromycin?

Spitting up is common in babies, but a few infants can hardly keep anything down. When the valve at the bottom of the stomach gets too tight, we call it pyloric stenosis, a condition that affects about 0.3% of babies.

The Centers for Disease Control and Prevention (CDC) reported a cluster of cases in 1999 in babies who had received erythromycin. I’ve also seen more cases of pyloric stenosis in 1999 than I usually do, (even though I am practicing less)- and these babies had not received erythromycin. Coincidence? Is pyloric stenosis really increasing? If so, why? If this has affected you, please let me know about your experience. One of the great benefits of the Internet is the acceleration of learning through shared knowledge.

Dr. Alan Greene

Dr. Greene is the founder of (cited by the AMA as “the pioneer physician Web site”), a practicing pediatrician, father of four, & author of Raising Baby Green & Feeding Baby Green. He appears frequently in the media including such venues as the The New York Times, the TODAY Show, Good Morning America, & the Dr. Oz Show.

  1. Marina S

    Hello Dr.Greene,
    Both of my twin sons got pryolic stenosis. I read your article, and here is our info. Both of our twins are my first borns, I’m Caucasian European, I’m 39 years and my husband is 44 and is of south asian roots. The babies are natural conceived and I never took erythromycin, but was I prescribed microbid against an uti, around 26 weeks into the pregnancy. I did take no other medications, except prenatal vitamins and delivered per c-section on 12/29/2015. There is not one case in both of our families of known PS, however I spit a lot then I was an first born infant, what lead my parents to call me fountain. We absolutely don’t understand how our twin boys got this, but surgery helped baby A so far. Baby B will need it too, which led me to read your article. If you have questions, we would love to answer to help so you maybe it helps to find a cure. Have a great day and good luck to find the answers you are looking for.
    Warm regards
    Marina S


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