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Fast Fact
A fasting blood sugar at or above 126 mg/dL or a random blood sugar at or above 200 mg/dL is diagnostic of diabetes, according to the official American Diabetes Association definition.
A fasting blood sugar of 100 to 125 mg/dL or a random blood sugar between 140 to 199 mg/dL is diagnostic of prediabetes, according to this same definition.
Prediabetes occurs when a person's blood glucose levels are higher than normal but not high enough to be diagnosed with type 2 diabetes.
The name, diabetes mellitus, comes from the Greek words for "to flow through" and "sweet." The Greek physicians used to diagnose the condition by actually tasting the urine. (That's dedication!)
Normally, a hormone called insulin pushes sugar from the blood into the body's cells where it can be used for fuel. The concentration of sugar in the blood remains within a fairly narrow range. If the body stops making insulin (type 1 diabetes), then adequate sugar doesn't get into the cells.
Until June 23, 1997, type 1 diabetes was also called insulin-dependent diabetes mellitus (IDDM).
Without insulin, muscle and fat begin to be burned for fuel (evidence of this -- ketones -- shows up in the urine). The person feels hungry all the time, but loses weight in spite of increased eating. Without replacement insulin, the person would eventually starve to death. Meanwhile, the concentration of sugar in the blood begins to increase. When the level reaches around 180 mg/dL, the sugar begins to spill over into the urine. This causes the person to make more urine and then to get thirstier, creating an accelerating cycle.
The classic symptoms of type 1 diabetes are increased urination (polyuria), increased thirst (polydipsia), increased eating (polyphagia) and weight loss. Anyone with the classic symptoms should have a blood sugar test as well as a urine test.
Occasionally people also report fatigue, blurred vision, vomiting, abdominal pain, or frequent skin infections.
If the disease remains undiagnosed, symptoms progress to include labored breathing, coma, and death.
People who get type 1 diabetes were born with a genetic predisposition to it. Not everyone born with this predisposition gets diabetes, however. In fact, if an identical twin has diabetes, the other twin gets it only about half the time.
Along the way, some of the predisposed individuals are exposed to something in the environment that triggers the diabetes. This is usually a viral infection. The virus misleads the body's immune system into making antibodies against its own pancreas cells that make insulin. (This is why type 1 diabetes is now also called immune-mediated diabetes.) The insulin-producing cells of the pancreas are gradually destroyed over time. When 90% of them have been destroyed, the person suddenly begins to develop symptoms.
Immune-mediated or type 1 diabetes most often strikes young people, especially between the ages of 5 and 7 (when viruses run through the schools), or at the time of puberty (when so many hormones change). For this reason, it used to be called juvenile-onset diabetes.
About 0.4% of the general public (or one out of 250) will eventually develop type 1 diabetes.
According to the National Diabetes Information Clearinghouse, just over 175,000 children under age 20 in the United States have diabetes.
About 800,000 people in the United States now have type 1 diabetes.
About 30,000 people develop type 1 diabetes each year.
Type 2 diabetes is caused, not by the absence of insulin, but by insulin's not working properly. It is much more frequent in overweight adults over the age of 45, but can occur at any age and weight. There are often no symptoms.
The National Institutes of Health estimates that more than 7 million adults in the United States have undiagnosed type 2 diabetes.
As obesity becomes more common among children, the number of children with prediabetes and with type 2 diabetes has been rising dramatically in recent years.
Dear Dr. Greene, I am a little concerned over the first paragraph in the section regarding when ventilation tubes are necessary in children. You state that the purpose of ventilation tubes is to allow bacteria and fluid to drain from the ear. This is incorrect.
Not only does this demonstrate a misunderstanding of the pathophysiology of otitis media, but also gives the wrong impression to parents that the insertion of tubes will be an ongoing problem with otorrhea.
Sincerely,
Patrick J. Fitzgerald, MD - Otolaryngology
Dear Dr. Fitzgerald, Thank you for sharing your concern. Although I have at least two readers review every answer before it is posted, I welcome additional input. It is an honor for me to be "reviewed" by other physicians.
After receiving your email, I re-read the answer you are referring to. It is to a reader who was concerned about when ear tubes should be used. That answer used to say, "This pressure-equalization (PE) tube provides a temporary, extra Eustachian tube to allow bacteria and fluid to drain from the middle ear." This statement was a shorthand summary of a more complicated process. I agree with you that it could lead parents to be concerned about fluid continually draining out of the ear. I have changed that entry to read, "This pressure-equalization (PE) tube provides a temporary, extra Eustachian tube which can help in several ways." That statement is linked to this page for a more complete explanation of how ear tubes facilitate the drainage of bacteria and fluid from the middle ear.
In the first half of the twentieth century, it was noticed that spontaneous holes in the eardrum often cured ear infections. These spontaneous holes, however, appeared and closed unpredictably. Several innovators tried various ways of keeping the holes open, including inserting fish bones, lead wires, and gold rings. Since 1954, the practice of intentionally making a small hole in the eardrum and inserting a small tube to keep the hole open has become very common. Today, more than 2 million ear tubes are implanted every year in the United States (Pediatric Clinics of North America, December 1996).
Ear tubes are made from a variety of materials, including ceramic, gold, plastic, Silastic, stainless steel, Teflon, and titanium. There is no proven advantage of one material over another.
A tube in the eardrum improves drainage of the middle ear space. Years ago, when a can of soda was opened with a can opener, a hole was made on both sides of the lid. While fluid poured out one hole, air was able to enter the can through the other, thus improving outflow. Ear tubes function in much the same way. When the middle ear space is closed, a suction effect prevents easy clearance of the contents down the eustachian tube. A blocked eustachian tube makes this even more difficult. When a tiny hole is made in the eardrum, the contents of the middle ear space flow far more easily either down the eustachian tube or out the inserted ear tube.
Unfortunately, this can also make it easier for bacteria to enter the middle ear space. It is easier for the contents of the nose and throat to travel up the eustachian tube if there is an opening at the other end. Also, bacteria can enter through the outer ear. Studies have shown, however, that for most children, improved drainage far outweighs the increased vulnerability.
It is my editorial goal to make every entry on Dr. Greene's HouseCalls the best piece of its length, for parents, that is available on the Internet or in print. Thank you, Dr. Fitzgerald, for helping me achieve my goal.
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