It also has a role in the treatment of chronic bronchitis, traveler's diarrhea, shigella, and in both the treatment and prevention of pneumocystis carinii pneumonia.
Most bacteria must manufacture their own supply of folic acid or folate. Animals (and some bacteria) depend on outside sources of folic acid, getting what they need from what they eat. Trimethoprim and sulfamethoxazole are both compounds that block the internal production of folic acid. Thus these compounds are relatively safe for humans, yet lethal to many bacteria.
The sulfamethoxazole component of Septra is a sulfa (or sulfur containing) drug. It causes fewer side effects than the other sulfa drugs, but its side effects should be respected.
The most common significant adverse effects are allergic skin reactions. Most of these are mild, but occasionally they are quite severe. Septra should be discontinued at the first sign of a skin rash.
Excess sun exposure should be avoided by anyone taking Septra.
Sulfa drugs may precipitate in the urine, producing crystals that can cause bleeding, urinary obstruction, or kidney damage. This is best prevented by using the most soluble of the more than 150 different sulfa drugs (such as the sulfamethoxazole in Septra) and by drinking lots of fluids while on the medication.
Allergic kidney damage can also occur, underscoring the need to stop taking Septra at the first signs of an allergic skin rash. When Septra is used on an ongoing basis, occasional blood and urine testing (a urinalysis, CBC, BUN, and creatinine) can detect early signs of problems.
Septra should not be used in children with folate deficiency.
Septra interacts with Dilantin, with methotrexate, and with anticoagulant medications; it should be used cautiously if these other drugs are being taken.
What’s the difference between bacteria and viruses?
Viruses are tiny geometric structures that can only reproduce inside a living cell. They range in size from 20 to 250 nanometers (one nanometer is one billionth of a meter). Outside of a living cell, a virus is dormant, but once inside, it takes over the resources of the host cell and begins the production of more virus particles. Viruses are more similar to mechanized bits of information, or robots, than to animal life.
Bacteria are one-celled living organisms. The average bacterium is 1,000 nanometers long. (If a bacterium were my size, a typical virus particle would look like a tiny mouse-robot. If an average virus were my size, a bacterium would be the size of a dinosaur over ten stories tall. Bacteria and viruses are not peers!) All bacteria are surrounded by a cell wall. They can reproduce independently, and inhabit virtually every environment on earth, including soil, water, hot springs, ice packs, and the bodies of plants and animals.
Most bacteria are harmless to humans. In fact, many are quite beneficial. The bacteria in the environment are essential for the breakdown of organic waste and the recycling of elements in the biosphere. Bacteria that normally live in humans can prevent infections and produce substances we need, such as vitamin K. Bacteria in the stomachs of cows and sheep are what enable them to digest grass. Bacteria are also essential to the production of yogurt, cheese, and pickles. Some bacteria cause infections in humans. In fact, they are a devastating cause of human disease.
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