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Recent headlines have trumpeted an exciting study about how pomegranate juice may prove very useful at preventing and even treating breast cancer. In test tubes, it’s proven quite effective against breast cancer cells. It turns out that pomegranate juice functions as something we call an aromatase inhibitor. Aromatase is an enzyme that takes testosterone and turns it into estrogen; it’s been linked to causing breast cancer. (This is one of the reasons I hate Atrazine, one of the most widely used pesticide weed killers in American agriculture: Atrazine stimulates aromatase. And we spray the stuff on our food!?). Aromatase inhibitor medicines are among the most exciting developments in preventing and treating breast cancer. And pomegranate juice contains clinically significant amounts.
As a pediatrician, my mind races to possible quicker benefits of pomegranate juice for kids:
(N.B. Most of today’s kids get too many sweet calories in their drinks, and I agree with the Academy of Pediatrics in recommending no more than 4 to 6 ounces a day of fruit juice before age 6, and no more than 8 to 12 ounces for older children.)
Pomegranates are one of 21 types of foods that I recommend in Feeding Baby Green to teach your child to love. Each of these diverse foods have been eaten by humans for thousands of years, and are packed with goodness we have yet to discover – and inhibiting aromatase is just the latest example.
I recently visited the King Tut exhibition at the de Young Museum in San Francisco and alerted my friends on Twitter when I learned that pomegranate seeds had been hidden in his tomb. Among the wealth of treasures there, this fruit is right at home.
Adams, L.S., Zhang, Y., Seeram, N.P., Heber, D., and Chen, S. “Pomegranate Ellagitannin-Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro.” Cancer Prevention, Jan 2010, 3(1):108-113.
Aksglaede, L., Skakkebaek, N.E., and Juul, A. “Recent Decline in Age at Breast Development: The Copenhagen Puberty Study.” Pediatrics, May 2009, 123(5):e932-939.
American Academy of Pediatrics, Committee on Nutrition. "The Use and Misuse of Fruit Juice in Pediatrics." Pediatrics, May 2001, 107(5):1210-1213.
Cernich, J., Jacobsen, J.D., Moore, W.V., and Popovic, J. “Use of Aromatase Inhibitors in Children with Short Stature.” Pediatric Endorcinologic Review, Sep 2004, 2(1):2-7.
Feuillan, P., Merke, D., Leschek, E.W., and Cutler, G.B. “Use of Aromatase Inhibitors in Precocious Puberty.” Endocrine-Related Cancer, 1999, 6:303-306.
Riepe, F.G., Baus, I., Wiest, S., Sippell, W.G., and Partsch, C.J. “Treatment of Pubertal Gynecomastia with the Specific Aromatase Inhibitor Anastrozole.” Hormone Research in Paediatrics, 2004, 62:(3):113-118.
Shulman D.I., Francis, G.L., Palmert, M.R., and Eugster, E.A. , for the Lawson Wilkins Pediatric Endocrine Society Drug and Therapeutics Committee. “Use of Aromatase Inhibitors in Children and Adolescent with Disorders of Growth and Adolescent Development.” Pediatrics, Apr 2008, 121(4):e975-983.
Comments
The active ingredient is the
The active ingredient is the pomegranate. Look for real pomegranates or juice made from lots of them. Be careful with blends. I recently came acriss Langers POMEGRANATE Juice Cocktail. Number one ingredient is water; number two is sugar. Probably tasty.
I love pomegranate juice! But
I love pomegranate juice! But I tend not to buy the full-strength juice because of the price. Are some of the less-pricey pomegranate blends just as helpful?
Unbelievable! Talk about
Unbelievable! Talk about "Food as Medicine" -- this is great stuff. Pomegranate juice anyone?