Our son was recently bit by a tick while on a day hike through tall grass. We found it on him while showering that evening. He has no symptoms. We are worried about Lyme disease. Can you tell us what we need to know?
Peter Iovan – San Mateo, California
Dr. Greene’s Answer:
The story of Lyme disease places us just inside the civilized frontier of the microscopic world. Even with our long history on this planet, new discoveries about microscopic neighbors continue to be made. In the 1970′s it was Legionnaire’s disease. In the 1980′s it was AIDS. In the 1990′s Hantavirus made the headlines.
The story of Lyme disease is particularly interesting for two reasons. One is that it illustrates the power of mothers to affect the health of their children, and two, it’s an excellent example of those many situations in our lives which if attended to at an early stage, are very simple to remedy, but if allowed to take root and grow become significant, difficult problems.
Lyme disease was first brought to medical attention in 1975, when two mothers living in Lyme, Connecticut became frustrated by the lack of concern given to the unusual illness spreading through their community on the banks of the Connecticut River. These two women began to clamor for an investigation. One contacted the Connecticut State Health Department, and the other contacted physicians at Yale Medical Center. Their initiative set in motion a massive investigation, which in 1982 culminated in the discovery by Dr. Burgdorfer and colleagues of the causative bacteria. It was named Borrelia burgdorferi. At the outset of the investigation, it was noticed that the incidence of Lyme Disease was 30 times greater on the East Bank of the Connecticut River than on the Western Bank. Interviews with affected children and adults and their neighbors revealed that those who exhibited the illness were much more likely to have a cat, a farm animal, a pet with ticks, or a tick bite in the year preceding the illness. As a result, ticks were identified as a likely mechanism for infection. Then, in 1982, Dr. Burgdorfer found the bacteria on the deer tick known as Ixodes dammini or Ixodes scapularis.
After the initial discovery, Lyme disease has been found in 49 of the 50 United States. It is primarily found on the eastern seaboard (between Maryland and Massachusetts), in the upper midwest (most notably Wisconsin and Minnesota), and in the west (particularly in California, Nevada, Utah, and Oregon). In fact, 7 states (Massachusetts, Rhode Island, Connecticut, New York, New Jersey, Wisconsin, and Minnesota) account for 90% of the cases of Lyme disease in the United States. The East Coast cases are transmitted by bites of the Ixodes scapularis tick, and in the West it is transmitted by the Ixodes pacificus tick. Lyme disease is the most common disease caused by a bite in the United States.
Lyme disease is also common in Europe (particularly in Scandinavian countries and in Central Europe — especially Germany, Austria, and Switzerland), but is found throughout the world, including in Australia where none of the ticks are known to exist. Humans are not the only ones susceptible to Lyme disease; dogs and horses also get it.
The bacteria live in deer and white-footed mice who do not develop the illness. When the appropriate tick feeds on one of these animals, it may become infected.
When an infected tick lands on someone, the bacteria are injected into the bloodstream through the saliva of the tick or deposited on the skin in tick feces. Thankfully, most ticks are not infected. In the North Eastern and Mid-Western United States only 15 to 20% of the nymphal stage deer ticks (those that typically transmit the disease) carry the bacteria. In the Western United States, only 1 to 3% of the ticks are infected. Even if someone is bitten by a nymphal stage deer tick that is infected, the risk of acquiring Lyme disease is only about 8 to 10%. It takes hours for the mouth parts of a tick to plant fully in the skin and much longer (days) for the tick to feed. Experiments have shown that it takes about 48 hours of feeding before the risk becomes substantial.
The symptoms in Lyme Disease can be divided into three stages. In the first stage a characteristic skin rash is the most prominent feature; in the second cardiac and neurologic findings predominate; and in the third stage arthritis is the classic symptom.
The classic early manifestation of Lyme disease is a round rash called erythema migrans. The rash usually occurs at the site of the bite 7 to 14 days after the tick bite, though it has occurred as early as 3 days and as long as 32 days later. Without treatment the rash gradually expands (hence the name migrans) to an average of 16 cm in diameter, but may be as large as 68 cm. The rash remains present for at least one to two weeks and usually twice that. At this stage, treatment is very simple, with amoxicillin or doxycycline. The symptoms usually resolve within several days. People with the skin lesions may have no other symptoms, but may also feel fatigue, headache, stiff neck, joint aches and pains, sometimes nausea, vomiting, and sore throat. There is often a low-grade fever, but it can be as high as 104 degrees F with chills.
Neurologic abnormalities occur roughly four weeks after the tick bite, but they can occur as early as two weeks after the bite and up to months or even years later with a wide spectrum of involvement. It may be something as mild as meningeal irritation and headache, but can be as severe as meningitis, encephalitis, chorea, and demyelination. Cardiac abnormalities occur in only about 10% of patients, averaging five weeks after the tick bite and thankfully are relatively brief, lasting no longer than six weeks.
The arthritis of the third stage usually begins five to six weeks after the bite, although it may occur as early as one week afterwards or as late as many months later. Large joints, often those closest to the initial rash, are affected most commonly.
The diagnosis is suspected because of the clinical picture, including the rash and/or flu-like illness in the summer. The diagnosis is confirmed by blood tests, although false negative and false positive blood tests are common.
Should you try to save the tick? It’s a good idea to bring the tick to your pediatrician or the public health department for visual identification. The current recommendation, however, is not to have all ticks actually tested for the Lyme bacteria, since even if present there is at least a 90% chance that the bitten person would not have contracted the disease.
Should everyone who is bitten get amoxicillin just in case? Experts have worked out what would happen if everyone who was bitten by a tick were to receive amoxicillin. Even though amoxicillin is a gentle antibiotic, there would be more suffering from side effects and allergic reactions than the suffering it would prevent by getting a jump start on treating those who actually have Lyme disease. It’s better to wait for the first signs and symptoms before treating.
There is a widespread misconception that Lyme disease is difficult to eradicate completely, once the chronic symptoms have appeared. This is not the case. Most cases of treatment failure have later turned out to be patients who did not actually have Lyme disease. The prognosis for children treated for Lyme disease is excellent no matter what stage treatment is begun. Still, if caught in the first stage, symptoms usually resolve within days, and if caught in later stages the symptoms themselves may not resolve for 12 to 16 months after treatment is begun.
In December 1998, a Lyme disease vaccine was approved by the FDA for persons 15-70 years of age. Those who visit or live in areas of high or moderate risk and whose activities result in exposure to vector ticks should discuss the possibility of vaccination with their physicians.
Before 1982 Borrelia burgdorferi was an unknown neighbor living just beyond the frontier of our knowledge, where other organisms are still waiting to be discovered. This successful, collaborative discovery expedition was launched by the persistent concern of two mothers from a small town. The disease itself is an outstanding example of the power of early detection and treatment to prevent long-term complications.Reviewed by: Khanh-Van Le-Bucklin
Last reviewed: January 01, 2004