depression anxiety with MTHFR gene mutation

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Submitted by Anonymous on February 18, 2010

My daughter who is 15 had a blood test done for MTHFR DNA mutation. She is positive for two copies of the C677T mutation. She has had depression and anxiety. We put her on Deplin (a prescription folic acid vitamin that bypasses missing enzymes.) She is 60% better. It seems like the doctors don't seem to see a connection with this, but I know its there. Any feedback?

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Anonymous's picture
Submitted by Anonymous on Fri, 2010-07-30 08:30.

I also have MTHFR and have

I also have MTHFR and have suffered from anxiety and depression for years. I've never been able to put my finger on the cause of my anxiety until now. I have a 5 yr old and a 2 yr old and I was faithful about taking my Foltex prescription (for MTHFR) while pregnant and for awhile after my children were born. About 4 months ago I ran out of my Foltex medication and thought that since I was no longer pregnanat I would probably be fine to stop taking my medication. Lately I have been experiencing symptoms of anxiety and depression again and now I know it is because I have stopped taking my Foltex. I absolutely believe MTHFR and depression and anxiety are connected. I scheduled an appointment with my doctor and will soon have my prescription refilled. When I am on my medication I feel fine, and therefore I will continue to take it always. I am glad your daughter is doing better and I wish you both a happy & healthy future.
Lorraine Settanni's picture
Lorraine Settanni

Hi I have 4 children with

Hi I have 4 children with mthfr mutations 2 with c677 and 2 with both c677 and a1268. It seems there is not much talk of the psychological effects. I have found that supplements with activated b12, folic acid and b-6 help a lot (we use a product for Medagenics, Neursol) amino acids with l-tryptophan in it (Livewell aminos by Jade Nutraceuticals) and watch for heavy metals as the immune system doesn't work as well. I found that mineral supplements of Colloida Life Trace minerals by Source Naturals helped with that. This site has a chart that is informative http://nwhealthcare.net/index.php?id=40 hope this helps. We see a chiropractor that helps adjust the supplement dosages.