Paget’s disease of the bone

Alternative Names

Osteitis deformans

Definition of Paget’s disease of the bone

Paget’s disease is a disorder that involves abnormal bone destruction and regrowth, which results in deformity.

Causes, incidence, and risk factors

The cause of Paget’s disease is unknown, although it might have to do with genes or a viral infection early in life.

Signs and tests

Tests that may indicate Paget’s disease include:


Not all patients need treatment. For example, patients who have abnormal blood tests only may not need treatment.

Expectations (prognosis)

Disease activity and symptoms can generally be controlled with current medications. A small percentage of patients may develop a cancer of the bone called . Some patients will need joint replacement surgery.


Ari S. Eckman, MD. Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Inc. – 11/23/2009


ADAM Medical Encyclopedia

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