Definition of Glucagonoma

Glucagonoma is a very rare of the islet cells of the pancreas, which release the hormones insulin and glucagon.

Causes, incidence, and risk factors

Glucagonoma is usually cancerous (malignant). The cancer tends to spread and get worse.

Signs and tests

Signs include:


Surgery to remove the tumor is the preferred treatment. The tumor does not respond to .

Expectations (prognosis)

Approximately 60% of these tumors are cancerous. Spread to the liver is common.


Sean O. Stitham, MD, private practice in Internal Medicine, Seattle, Washington; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. – 9/4/2008

Endocrine glands

ADAM Medical Encyclopedia

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