Congenital protein C or S deficiency

Alternative Names

Protein S deficiency; Protein C deficiency

Definition of Congenital protein C or S deficiency

Congenital protein C or S deficiency is a lack of proteins C or S in the fluid part of the blood. The proteins are natural substances that help prevent blood clots.

Causes, incidence, and risk factors

Congenital protein C or S deficiency is an inherited disorder, which means it is passed down through families. Congenital means it is present at birth.

Symptoms

If you have this condition, you are more likely to develop blood clots. The symptoms are the same as for deep venous thrombosis, and include:

Signs and tests

Laboratory tests will be done to check for proteins C and S. If you have this disorder, you will have a lack of protein C or S.

Treatment

Blood-thinning drugs (heparin and warfarin) are used to treat and prevent blood clots.

Expectations (prognosis)

The outcome is usually good with treatment, but symptoms may return.

Review

David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. – 3/28/2010

Blood clot formation
Blood clots

ADAM Medical Encyclopedia

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